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AssigneeTallinn University of Technology
InventorsVitali SÕRITSKI, Jekaterina REUT, Roman BOROZNJAK, Anna KIDAKOVA, Andres ÖPIK, Abdul RAZIQ, Kaspar RATNIK, Paul NAABER
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The current COVID-19 pandemic caused by SARS-CoV-2 coronavirus is expanding around the globe. Hence, accurate and cheap portable sensors are crucially important for the clinical diagnosis of COVID-19. Molecularly imprinted polymers (MIPs) as robust synthetic molecular recognition materials with antibody-like ability to bind and discriminate between molecules are provided here as selective elements in such sensors. Provided are detection assemblies comprising electrochemical sensors having ncovNP-MIP film endowed selectivity against SARS-CoV-2 nucleoprotein (ncovNP) and/or ncovS1-MIP film endowed selectivity against SARS-CoV-2 spike 1 (S1). The ncovNP- or ncovS1-MIP are synthesized electrochemically on portable gold thin-film electrodes system via chronocoulometry or cyclic voltammetry. The sensors show excellent detection capabilities, and high discrimination of interfering proteins.
A detection assembly for detecting at least one SARS-CoV-2 antigen from a sample, the assembly comprising portable electrochemical sensor integrated with a SARS-CoV-2 antigen-molecular imprinted polymer (MIP), wherein the SANS-CoV-2 antigen-MIP is configured to act as a synthetic recognition element selectively detecting and binding the at least one SARS-CoV-2 antigen;
A method to detect presence or absence or quantitative concentration of at least one SARS-CoV-2 antigen in a sample, wherein the method comprises:
A method for making an electrochemical sensor for detection SARS-CoV-2 antigen, especially ncovNP or ncovS1 from samples, the method comprising the steps of:
Dependencies are inferred from the claim text.