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US 2023/0408461 A1Published application
Lc/ms adduct mitigation by vapor deposition coated surfaces
AssigneeWaters Technologies Corporation
InventorsKerri M. Smith, Paul Rainville
Life of this patent
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Abstract
The present disclosure discusses a method of separating a sample (e.g., small organic acid metabolite) including coating a flow path of a chromatographic system. The coating along the flow path is vapor deposited and prevents or severely decreases metal interactions between the metallic chromatographic system and the sample.
Claims11
1-20. (canceled)
A method of separating and analyzing critical pairs in a sample comprising:
- injecting the sample into a chromatographic system having a fluid-contacting coating on a metallic surface defining a sample flow path, wherein the coating comprises an alkylsilyl coating made using vapors of bis(trichlorosilyl)ethane or bis(trimethoxysilyl)ethane, and the sample comprises two or more structural isomers defining the critical pairs;
- flowing the injected sample through the chromatographic system along the sample flow path;
- separating the flowing sample with the chromatographic system;
- and
- analyzing separated critical pairs with a mass spectrometer.
2 more elements
Dependencies are inferred from the claim text.