Column in a module with internal or external on-column or flow cell detectors with optional heating for liquid chromatography

A liquid chromatography (LC) system, said system comprising:

• an LC device comprising:
• a pump, a solvent and a sample;
• an injector for delivering the sample in the solvent;
• a connection dock for providing an LC output port to enable the injector to deliver the sample in the solvent to the output port, an LC input port, and a first electrical port;
• at least one detector coupled to the LC input port for receiving the sample in the solvent and for performing detection of substances in the sample in the solvent;
• and
• a separate module that is attached to the LC device,
• the module comprising:
• a module input port for forming a high pressure compression connection to the LC output port and receiving the sample in the solvent;
• a second electrical port that is coupled to the first electrical port;
• a first column coupled at a first end to the module input port for receiving the sample in the solvent, wherein the first column is transparent or opaque, and wherein the first column is coupled at a second end to the module output port;
• a heating unit;
• a column oven disposed around the heating unit and at least a portion of the first column;
• and
• wherein the results of separating, identifying and quantifying of substances are transmitted from the module to a computing device using the first and the second electrical ports.

A liquid chromatography (LC) system, said system comprising:

• an LC device comprising:
• a pump, a solvent and a sample;
• an injector for delivering the sample in the solvent;
• a connection dock for providing an LC output port to enable the injector to deliver the sample in the solvent to the output port, an LC input port, and a first electrical port;
• and
• a separate module that is attached to the LC device,
• the module comprising:
• a module input port for forming a high pressure compression connection to the LC output port and receiving the sample in the solvent;
• a second electrical port that is coupled to the first electrical port;
• a first column coupled at a first end to the module input port for receiving the sample in the solvent, wherein the first column is transparent or opaque, and wherein the first column is coupled at a second end to the module output port;
• a heating unit;
• a column oven disposed around the heating unit and at least a portion of the first column;
• and
• at least one detector coupled to the module output port for receiving the sample in the solvent and for performing detection of substances in the sample in the solvent, and wherein the results of separating, identifying and quantifying of substances are transmitted from the module to a computing device using the first and the second electrical ports.

A liquid chromatography (LC) system, said system comprising:

• an LC device comprising:
• a pump, a solvent and a sample;
• an injector for delivering the sample in the solvent;
• a connection dock for providing an output port to enable the injector to deliver the sample in the solvent to the output port, and a first electrical port;
• and
• a separate module that is attached to the LC device,
• the module comprising:
• a module input port for forming a high pressure compression connection to the output port and receiving the sample in the solvent;
• a second electrical port that is coupled to the first electrical port;
• a first column coupled at a first end to the module input port for receiving the sample in the solvent, wherein the first column is opaque or transparent;
• a heating unit;
• a column oven disposed around the heating unit and at least a portion of the column;
• and
• at least one flow cell detector for performing detection of substances in the sample in the solvent, wherein the first column and the detector perform separating, identifying and quantifying of substances;
• and
• wherein the results of separating, identifying, and quantifying of substances are transmitted from the module to a computing device using the first and the second electrical ports.

A liquid chromatography (LC) system, said system comprising:

• an LC device comprising:
• a pump, a solvent and a sample;
• an injector for delivering the sample in the solvent;
• a connection dock for providing an LC output port to enable the injector to deliver the sample in the solvent to the output port, an LC input port, and a first electrical port;
• at least one flow cell detector coupled to the LC input port for receiving the sample in the solvent and for performing detection of substances in the sample in the solvent;
• and
• a separate module that is attached to the LC device,
• the module comprising:
• a module input port for forming a high pressure compression connection to the LC output port and receiving the sample in the solvent;
• a second electrical port that is coupled to the first electrical port;
• a first column coupled at a first end to the module input port for receiving the sample in the solvent, wherein the first column is transparent or opaque, and wherein the first column is coupled at a second end to the module output port;
• a heating unit;
• a column oven disposed around the heating unit and at least a portion of the first column;
• and
• wherein the results of separating, identifying and quantifying of substances are transmitted from the module to a computing device using the first and the second electrical ports.

A liquid chromatography (LC) system, said system comprising:

• an LC device comprising:
• a pump, a solvent and a sample;
• an injector for delivering the sample in the solvent;
• a connection dock for providing an LC output port to enable the injector to deliver the sample in the solvent to the output port, an LC input port, and a first electrical port;
• and
• a separate module that is attached to the LC device,
• the module comprising:
• a module input port for forming a high pressure compression connection to the LC output port and receiving the sample in the solvent;
• a second electrical port that is coupled to the first electrical port;
• a first column coupled at a first end to the module input port for receiving the sample in the solvent, wherein the first column is transparent or opaque, and wherein the first column is coupled at a second end to the module output port;
• a heating unit;
• a column oven disposed around the heating unit and at least a portion of the first column;
• and
• at least one flow cell detector coupled to the module output port for receiving the sample in the solvent and for performing detection of substances in the sample in the solvent, and wherein the results of separating, identifying and quantifying of substances are transmitted from the module to a computing device using the first and the second electrical ports.

A method of performing liquid chromatography (LC) for separating, identifying and quantifying substances in a sample, said method comprising:

• providing an LC device comprising a pump, a solvent and a sample, an injector for delivering the sample in the solvent, a connection dock for providing fluid ports to enable the injector to deliver the sample in the solvent to an LC output port, and a first electrical port, and
• providing a separate module that is attached to the LC device, the module comprising a module input port for forming a high pressure compression connection to the LC output port and receiving the sample in the solvent, a second electrical port that is coupled to the first electrical port, a column coupled at a first end to the module input port for receiving the sample in the solvent, wherein the first column is transparent or opaque, a heating unit, a column oven disposed around the heating unit and at least a portion of the first column, and at least one detector for performing detection of substances in the sample in the solvent, wherein the column and detector perform separating, identifying and quantifying of substances,
• performing LC by attaching the module to the LC device using the high pressure compression connection;
• injecting the sample in the solvent to the column in the module;
• separating the sample in the solvent;
• identifying substances in the sample in the solvent based on how the sample interacts with sorbent material in the column;
• quantifying the substances in the sample;
• and
• transmitting data regarding the substances from the module to a computing device using the first and the second electrical port.