Loading patent…
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsNir Hacohen, Ang Cui
Estimating the term…
The present disclosure provides methods for determining signatures of immune responses to immunomodulating agents in cells and in tissues. Also provided herein are computational methods for deconvoluting gene expression profiling data. Further provided herein are methods for treating a disease or disorder (e.g, proliferative diseases such as cancer, autoimmune diseases such as rheumatoid arthritis and psoriasis, allergies, etc.) in a subject comprising administering one or more immunomodulating agents to drive an immune response, in combination with a treatment for the disease or disorder (e.g, an anti-cancer therapy, an anti-viral therapy, a vaccination, etc.).
A method for determining signatures of immune responses to immunomodulating agents, the method comprising steps of:
A method for treating a disease or disorder in a subject in need thereof, the method comprising administering one or more immunomodulating agents that drive an immune response within the subject in combination with a treatment for the disease or disorder, wherein the immune response is associated with increased efficacy of the treatment.
A method of polarizing a population of cells, the method comprises stimulating the cells with IL7r, Gzmb, Isg15, Klra4, Srm, or Mcm5.
A method of expanding a population of cells, the method comprising stimulating the cells with an immunomodulating agent.
A method of treating cancer, the method comprising administering IL18 to a subject in need thereof in combination with a cancer therapy.
A method for treating cancer, the method comprising administering an anti-cancer therapy in combination with inducing GZMB expression in a subject in need thereof.
A method for treating a viral infection, the method comprising administering an anti-viral treatment in combination with inducing GZMB expression in a subject in need thereof.
A method of vaccination, the method comprising administering a vaccine and stimulating IFNa, IFNb, TFNa, IL15, IL18, IL1a, IFNk, IL36α, IFNg, Flt3I, OX40L, BAFF, IFNg, Flt3I, IL6, IL27, IL36-RA, IL34, or GM-CSF in a subject in need thereof
Dependencies are inferred from the claim text.