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US 2023/0407335 A1Published application
Methods for Preparing Genetically Modified Cells
AssigneesShanghai Cellular Biopharmaceutical Group Ltd., Cellular Biomedicine Group, Inc., Cellular Biomedicine Group Hk Limited
InventorsShichao QIN, Lili ZHAI, Zizhen GONG, Fei WANG, Dijun ZHAO, Junfeng WU, Li ZHANG, Hanqing ZHANG, Luyi ZHANG
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Abstract
The present disclosure provides methods for improving the preparation efficiency of genetically modified immune cells and improving the quality of immune cells.
Claims23
A method for preparing genetically modified immune cells, the method comprising:
- (a) providing a sample containing immune cells;
- (b) sorting the sample to obtain a first immune cell population enriched in immune cells;
- (c) activating the first immune cell population to obtain a second immune cell population;
- (d) culturing the second immune cell population to obtain a third immune cell population;
- (e) genetically modifying the third immune cell population to obtain a fourth immune cell population;
- and
- (f) culturing the fourth immune cell population to obtain genetically modified immune cells.
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Dependencies are inferred from the claim text.