Antisense oligomers for treatment of disease
AssigneesMonash University, Murdoch University
InventorsStephen Wilton, May Aung-Htut, Merlin Christopher Thomas, Raelene Jane Pickering
Life of this patent
Estimating the term…
Abstract
An isolated or purified antisense oligomer for modifying pre-mRNA splicing in the Angiotensin Converting Enzyme 2 (ACE2) to modulate splicing of the ACE2 gene transcript or part thereof which has a modified backbone structure and sequences with at least 75% sequence identity to such antisense oligomers and which have a modified backbone structure.
Claims15
An isolated or purified antisense oligomer for modifying pre-mRNA splicing in the Angiotensin Converting Enzyme 2 (ACE2) to modulate splicing of the ACE2 gene transcript or part thereof which has a modified backbone structure and sequences with at least 75% sequence identity to such antisense oligomers and which have a modified backbone structure.
(canceled)
The composition of claim 15 wherein the combination of antisense oligomers is chosen from the combination SEQ ID NO:
- 6 and 9 or SEQ ID NO:
- 6 and 11.
Dependencies are inferred from the claim text.