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US 2023/0407277 A1Published application
Engineered CRISPR-Cas9 Nucleases with Altered PAM Specificity
AssigneeThe General Hospital Corporation
InventorsJ. Keith Joung, Benjamin Kleinstiver
Life of this patent
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Abstract
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
Claims26
1-35 (canceled)
A base editor protein comprising a PAM interacting domain that has mutations at positions corresponding to D1135, S1136, and G1218 of SEQ ID NO:1, wherein the mutation at D1135 is M, the mutation at S1136 is Q, and the mutation at G1218 is K.
Dependencies are inferred from the claim text.