Treatment of disc degenerative disease and stimulation of proteoglycan synthesis by fibroblast conditioned media and formulations thereof
AssigneeFigene, LLC
InventorsPete O'Heeron, Thomas Ichim
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Abstract
In some aspects, disclosed are methods and compositions for disc regeneration and/or repair using one or more components from conditioned media from fibroblasts. In certain cases, conditioned media is obtained from fibroblasts stimulated with one or more opioid receptor antagonists and one or more toll-like receptor agonists. Conditioned media from fibroblasts may be provided in an effective amount to an individual in need thereof.
Claims53
A composition, comprising one or more components derived from fibroblast cells cultured with one or more opioid receptor antagonists and one or more toll-like receptor (TLR) agonists.
A method of promoting disc regeneration in an individual, the method comprising providing to the individual an effective amount of one or more components derived from a fibroblast cell cultured with one or more opioid receptor antagonists and one or more toll-like receptor (TLR) agonists.
A method of promoting disc regeneration in an individual, the method comprising providing to the individual an effective amount of fibroblast cells previously cultured with one or more opioid receptor antagonists and one or more toll-like receptor (TLR) agonists.
A method of generating one or more components from fibroblast cells, the method comprising culturing the fibroblast cells with one or more opioid receptor antagonists and one or more toll-like receptor (TLR) agonists.
A method for improving an efficacy of a tolerogenic therapy, the method comprising:
- (a) providing the tolerogenic therapy to an individual;
- and
- (b) providing to the individual an effective amount of one or more opioid receptor antagonists sufficient to enhance the efficacy of the tolerogenic therapy.
Dependencies are inferred from the claim text.