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AssigneeGi Cell, Inc.
InventorsMyoung Ho JANG, Chun-Pyo HONG, Chea Ha KIM, Hye Ri KIM
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The present invention relates to a method for effectively proliferating regulatory T cells, by which, particularly, in the presence of a fusion protein dimer comprising IL-2. protein or a variant thereof and CD80 protein or a fragment thereof, CD4+, CD25+, and CD127− T cells can be effectively proliferated. In particular, when combined with a predetermined cell culture medium, regulatory T cells such as CD4+, CD25+, and CD127− can be effectively and specifically proliferated. In addition, when the method is used, it has been confirmed that the survival rate of regulatory T cells is remarkably increased as compared to a conventionally used culture method using IL-2, and a significant increase in the yield of Foxp3+ regulatory T cells has been confirmed. Thus, such a proliferation method can be used in the field of cell therapeutic agents using regulatory T cells.
A composition for proliferating regulatory T cells comprising, as an active ingredient, a fusion protein dimer containing an IL-2 protein or a variant thereof and a CD80 protein or a fragment thereof.
A medium for proliferating regulatory T cells comprising a fusion protein dimer containing an IL-2 protein or a variant thereof and a CD80 protein or a fragment thereof.
A method for culturing a regulatory T cells comprising:
Dependencies are inferred from the claim text.