Grafted polymer and use thereof
AssigneeBausch + Lomb Ireland Limited
InventorsJames Anthony DiBella, JR., Alok Kumar Awasthi, Jade J. Russell, Mark R. Mis, James Hauenstein, Mark Fomalik, Andrew J. Hoteling, Shawn M. Conlon, Kaushiendra Kumar
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Abstract
A grafted glycosaminoglycan polymer is disclosed. The grafted glycosaminoglycan polymer comprises a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.
Claims20
A crosslinked polymeric network comprising a reaction product comprising a grafted glycosaminoglycan polymer comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone, and one or more crosslinking agents.
A biomedical device having a coating on a surface thereof, the coating comprising a grafted glycosaminoglycan polymer comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone.
A packaging system for the storage of an ophthalmic device comprising a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising a grafted glycosaminoglycan polymer comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is sterilized.
A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising:
- (a) immersing an ophthalmic device in an aqueous packaging solution comprising a grafted glycosaminoglycan polymer comprising a glycosaminoglycan having a polymer backbone and one or more side chains comprising a polyalkylene glycol-containing residue grafted onto the polymer backbone, wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9;
- (b) packaging the aqueous packaging solution and the ophthalmic device in a manner preventing contamination of the ophthalmic device by microorganisms;
- and
- (c) sterilizing the packaged aqueous packaging solution and the ophthalmic device.
Dependencies are inferred from the claim text.