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US 2023/0406927 A1Published application
Masked single-domain antibodies and methods thereof
AssigneeRegents of the University of Minnesota
InventorsCarston R. Wagner, Abhishek Kulkarni
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Abstract
Certain embodiments of the invention provide a masked single-domain antibody as described herein, as well as methods of use thereof. Certain embodiments of the invention provide a masked CSAN as described herein, as well as methods of use thereof.
Claims26
A recombinant protein, comprising a masking polypeptide linked to a single-domain antibody (sdAb), or an antigen binding fragment thereof, via a protease-sensitive polypeptide linker, wherein the binding affinity of the sdAb, or the antigen binding fragment thereof, to its target antigen is reduced by the masking polypeptide.
Dependencies are inferred from the claim text.