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AssigneesThe Johns Hopkins University, Fundacion Instituto Lelior, Consejo Nacional de Investigacion Cientifica y Tecnica (CONICET)
InventorsSandra B. Gabelli, Leon M. Amzel, Lakshmi Srinivasan, Vanina Alzogaray, Manu Ben-Johny
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Provided herein a single-domain antibodies (sdAbs) that bind to voltage-gated sodium channel (Nav)1.4 or Nav1.5 and polynucleotides encoding the sdAb. Also provided herein are expression cassettes, vectors and host cells including polynucleotides N encoding the sdAb, and pharmaceutical composition including the sdAb, and methods of use thereof. The methods include the detection and/or capture Nav1.4 or Nav1.5 in a sample, the detection of a disease or condition in a subject, and the treatment of cardiac arrhythmia, myotonia, sudden cardiac death syndrome or cancer in a subject using sdAbs that bind Nav 1.4 or Nav 1.5.
A single-domain antibody (sdAb) that binds to voltage-gated sodium channel (Nav)1.4 or Nav1.5, wherein the sdAb comprises:
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A method of treating cardiac arrhythmia, myotonia or sudden cardiac death syndrome in a subject comprising administering to the subject a single-domain antibody (sdAb) that binds to voltage-gated sodium channel (Nav)1.4 or Nav1.5 for tissue-specific targeting of Nav1.4 or Nav1.5, thereby treating the treating cardiac arrhythmia, myotonia or sudden cardiac death syndrome.
A method of treating cancer in a subject comprising administering to the subject a single-domain antibody (sdAb) that binds to voltage-gated sodium channel (Nav)1.4 or Nav1.5 for tissue-specific targeting of Nav1.4 or Nav1.5, thereby treating the cancer.
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Dependencies are inferred from the claim text.