Method for producing influenza ha split vaccine
AssigneeJapan AS Represented By Director-General of National Institute of Infectious Diseases
InventorsYoshimasa Takahashi, Yu Adachi, Manabu Ato
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Abstract
Provided is a method for producing an influenza HA split vaccine which produces an antibody that binds to a HA stem region of influenza, the HA stem region being less likely to cause antigenic variation, An influenza HA split vaccine is subjected to an acidic treatment. Through the acidic treatment, an influenza HA split vaccine which produces an antibody that binds to a LAH of the HA stem region is obtained. This influenza HA split vaccine has an excellent protective ability against infection of other influenza viruses of different antigenicity.
Claims15
1-7. (canceled)
An influenza haemagglutinin (HA) split vaccine, wherein
- the influenza HA split vaccine is capable of producing an antibody that binds to a long alpha helix (LAH) of a HA stem region, and
- the influenza HA split vaccine is produced by a method comprising:
- subjecting an influenza HA split vaccine to an acidic treatment.
An influenza HA split vaccine, wherein
- the influenza HA split vaccine is capable of producing an antibody that binds to a LAH of a HA stem region, and
- the influenza HA split vaccine is produced by mixing two or more of influenza HA split vaccine antigens wherein each of said two or more of influenza HA split vaccine antigens is produced by a method comprising:
- subjecting an influenza HA split vaccine including a single subtype to an acidic treatment.
Dependencies are inferred from the claim text.