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US 2023/0406905 A1Published application
Hemostatic nanoparticles for the treatment of non-compressible hemorrhage and internal bleeding
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsPaula T. Hammond Cunningham, Bradley D. Olsen, George Velmahos, Celestine Jia Huey Hong
Life of this patent
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Abstract
An injectable nanoparticular formulation and method of use thereof for treating non-compressible hemorrhage or internal bleeding has been developed. The formulation includes two interactive components, one a targeting nanoparticle with a polypeptide sequence that binds to a cell present at a site of injury, and the other a crosslinking nanoparticle with a bioorthogonal click-crosslinking group.
Claims24
A composition comprising
- an interactive two-component system consisting of a targeting component and a crosslinking component, preferably a dendrimer, a star polymer, a polyelectrolyte or a nanoparticle.
Dependencies are inferred from the claim text.