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US 2023/0406898 A1Published application
Fusion proteins comprising progranulin
AssigneeDenali Therapeutics Inc.
InventorsGilbert Di Paolo, Todd P. Logan, Kathryn M. Monroe, Ankita Srivastava, Bettina Van Lengerich
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Abstract
Provided herein are fusion proteins that comprise progranulin and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
Claims46
1-159. (canceled)
A protein comprising:
- (a) a first Fc polypeptide that is linked to a progranulin polypeptide or a variant thereof;
- and
- (b) a second Fc polypeptide that forms an Fc dimer with the first Fc polypeptide,
- wherein the second Fc polypeptide specifically binds to a transferrin receptor.
1 more element
A polypeptide comprising an Fc polypeptide that is linked to a progranulin polypeptide or a variant thereof, wherein the Fc polypeptide contains one or more modifications that promote its heterodimerization to another Fc polypeptide.
Dependencies are inferred from the claim text.