US 2023/0406892 A1Published application

Bacteriocins for control of salmonella enterica

AssigneeNomad Bioscience GmbH

InventorsSimone Hahn, Tobias Schneider, Anett Stephan, Steve Schulz, Anatoli Giritch, Yuri Gleba, Heike Prochaska

Life of this patent

Estimating the term…

Abstract

The present invention relates to bacteriocins for control of Salmonella enterica (salmocins). The bacteriocins are derived from Salmonella. The salmocins can be expressed in plants and can be used in a method of preventing or reducing infection or contamination of an object with Salmonella.

Claims28

Dependent claims

A protein comprising at least any one of the following amino acid sequence segments:

(a-vii) the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(a-viii) the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(a-ix) the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(a-x) the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28),
(a-xi) the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(a-xii) the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34);
or
(b-vii) a segment having at least 70% sequence identity to the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(b-viii) a segment having at least 70% sequence identity to the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(b-ix) a segment having at least 70% sequence identity to the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(b-x) a segment having at least 70% sequence identity to the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28);
(b-xi) a segment having at least 70% sequence identity to the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(b-xii) a segment having at least 70% sequence identity to the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34);
or
(c-vii) a segment having at least 80% sequence similarity to the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(c-viii) a segment having at least 80% sequence similarity to the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(c-ix) a segment having at least 80% sequence similarity to the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(c-x) a segment having at least 80% sequence similarity to the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28),
(c-xi) a segment having at least 80% sequence similarity to the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(c-xii) a segment having at least 80% sequence similarity to the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34);
or
(d-vii) a segment having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(d-viii) a segment having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(d-ix) a segment having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(d-x) a segment having from 1 to 30 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28),
(d-xi) a segment having from 1 to 30 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(d-xii) a segment having from 1 to 30 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34).

48 more elements

A protein comprising or consisting of any one of the following amino acid sequences:

(A-vii) SEQ ID NO:
25,
(A-viii) SEQ ID NO:
26,
(A-ix) SEQ ID NO:
27,
(A-x) SEQ ID NO:
28,
(A-xi) SEQ ID NO:
33, or
(A-xii) SEQ ID NO:
34;
or
(B-vii) an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:
25,
(B-viii) an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:
26,
(B-ix) an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:
27,
(B-x) an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:
28,
(B-xi) an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:
33, or
(B-xii) an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO:
34;
or
(C-vii) an amino acid sequence having at least 80% sequence similarity to the amino acid sequence of SEQ ID NO:
25,
(C-viii) an amino acid sequence having at least 80% sequence similarity to the amino acid sequence of SEQ ID NO:
26,
(C-ix) an amino acid sequence having at least 80% sequence similarity to the amino acid sequence of SEQ ID NO:
27,
(C-x) an amino acid sequence having at least 80% sequence similarity to the amino acid sequence of SEQ ID NO:
28,
(C-xi) an amino acid sequence having at least 80% sequence similarity to the amino acid sequence of SEQ ID NO:
33, or
(C-xii) an amino acid sequence having at least 80% sequence similarity to the amino acid sequence of SEQ ID NO:
34;
or
(D-vii) an amino acid sequence having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the amino acid sequence of SEQ ID NO:
25,
(D-viii) an amino acid sequence having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the amino acid sequence of SEQ ID NO:
26,
(D-ix) an amino acid sequence having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the amino acid sequence of SEQ ID NO:
27, or
(D-x) an amino acid sequence having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the amino acid sequence of SEQ ID NO:
28,
(D-xi) an amino acid sequence having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the amino acid sequence of SEQ ID NO:
33, or
(D-xii) an amino acid sequence having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the amino acid sequence of SEQ ID NO:
34;
or
(E-vii) an amino acid sequence comprising or consisting of at least 425 contiguous amino acid residues of SEQ ID NO:
25,
(E-viii) an amino acid sequence comprising or consisting of at least 425 contiguous amino acid residues of SEQ ID NO:
26,
(E-ix) an amino acid sequence comprising or consisting of at least 425 contiguous amino acid residues of SEQ ID NO:
27,
(E-x) an amino acid sequence comprising or consisting of at least 215 contiguous amino acid residues of SEQ ID NO:
28,
(E-xi) an amino acid sequence comprising or consisting of at least 215 contiguous amino acid residues of SEQ ID NO:
33, or
(E-xii) an amino acid sequence comprising or consisting of at least 215 contiguous amino acid residues of SEQ ID NO:
34.

61 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/761,854Filed 21 Sep 2020
Priority: EP 17 162 784.724 Mar 2017
Published: 21 Dec 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
C07K 14/461
From vertebrates: from fish
A23K 20/147
Amino acids; Derivatives thereof: polymeric derivatives, e.g. peptides or proteins
A61K 38/164
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from bacteria

Family

Application16/577,484Continuation · filed 20 Sep 2019
Application17/761,854Continuation
Application16/577,484Continuation in part
US 11,161,886 B2Related patent
US 2020/0010517 A1Published application
US 2023/0406892 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

A protein comprising at least any one of the following amino acid sequence segments:

(a-vii) the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(a-viii) the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(a-ix) the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(a-x) the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28),
(a-xi) the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(a-xii) the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34);
or
(b-vii) a segment having at least 70% sequence identity to the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(b-viii) a segment having at least 70% sequence identity to the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(b-ix) a segment having at least 70% sequence identity to the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(b-x) a segment having at least 70% sequence identity to the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28);
(b-xi) a segment having at least 70% sequence identity to the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(b-xii) a segment having at least 70% sequence identity to the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34);
or
(c-vii) a segment having at least 80% sequence similarity to the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(c-viii) a segment having at least 80% sequence similarity to the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(c-ix) a segment having at least 80% sequence similarity to the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(c-x) a segment having at least 80% sequence similarity to the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28),
(c-xi) a segment having at least 80% sequence similarity to the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(c-xii) a segment having at least 80% sequence similarity to the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34);
or
(d-vii) a segment having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 195 to 319 of ScolE1c (SEQ ID NO:
25),
(d-viii) a segment having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 195 to 319 of ScolE1d (SEQ ID NO:
26),
(d-ix) a segment having from 1 to 40 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 193 to 317 of ScolE1e (SEQ ID NO:
27),
(d-x) a segment having from 1 to 30 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 38 to 138 of ScolMa (SEQ ID NO:
28),
(d-xi) a segment having from 1 to 30 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 38 to 138 of ScolMb (SEQ ID NO:
33), or
(d-xii) a segment having from 1 to 30 amino acid substitutions, additions, insertions or deletions to the segment from amino acid residue 38 to 138 of ScolMc (SEQ ID NO:
34).

48 more elements

Facts

Application

17/761,854Filed 21 Sep 2020

Priority

EP 17 162 784.724 Mar 2017

Published

21 Dec 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
C07K 14/461
From vertebrates: from fish
A23K 20/147
Amino acids; Derivatives thereof: polymeric derivatives, e.g. peptides or proteins
A61K 38/164
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from bacteria