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US 2023/0406889 A1Published application
Live-attenuated flaviviruses with heterologous antigens
AssigneeKatholieke Universiteit Leuven
InventorsRobbert Boudewijns, Kai Dallmeier, Johan Neyts
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Abstract
The invention relates to polynucleotides comprising the sequence of a flavivirus preceded by a sequence encoding an N terminal part of a flavivirus Capsid protein, an immunogenic protein, or a part thereof comprising a an immunogenic peptide, and a 2A cleaving peptide, and to the virus encoded by such sequences. The invention further relates to the use of such polynucleotides and viruses as vaccines.
Claims18
A polynucleotide comprising the sequence of a flavivirus characterized in that the nucleotide sequence encoding said flavivirus is preceded by a sequence encoding:
- a part of a flavivirus Capsid protein comprising or consisting of the N terminal part of the flavivirus Capsid protein,
- an immunogenic protein, or a part thereof comprising an immunogenic peptide, and
- a 2A cleaving peptide.
Dependencies are inferred from the claim text.