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US 2023/0406846 A1Published application
Novel fxr agonist having pyrazine structure, and preparation method and use
AssigneeJiangsu Tasly Diyi Pharmaceutical Co., Ltd.
InventorsWeiwei MA, Guocheng WANG
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Abstract
The present invention relates to a novel FXR agonist having a pyrazine structure, a preparation method therefor and the use thereof, and in particular relates to a compound as represented by the following general formula (I), or a hydrate, a solvate or a pharmaceutically acceptable salt thereof or a resolved single isomer thereof, which has the effect of treating non-alcoholic fatty liver disease.
Claims11
A compound having the structure of Formula (I):
- wherein
- R1 is halogen, —COOH,
- R2 is C1-C6 alkyl, cyclic hydrocarbyl, aryl, substituted alkyl, or substituted aryl;
- R3 is —H, C1-C3 alkyl, cyclic hydrocarbyl, or substituted alkyl;
- and,
- X is C or N,
- or a hydrate, a solvate, a pharmaceutically acceptable salt, or a resolved single isomer thereof.
4 more elements
Dependencies are inferred from the claim text.