US 2023/0406834 A1 · PREPARATION METHOD FOR CANNFLAVIN COMPOUNDS

Abstract

Disclosed in the present invention is a preparation method for cannflavin compounds. The preparation method has advantages such as cheap and easily available raw materials, few reaction steps, short production period, and easy operation. The method comprises: first, condensing 4′-hydroxy-3′-methoxyacetophenone and diethyl carbonate (DEC) under an alkaline condition to obtain ethyl 4′-hydroxy-3′-methoxybenzoylacetate, next, reacting 1,3,5-trihydroxybenzene with geraniol to obtain (E)-2-(3,7-dimethyloct-2,6-dien-1-yl)benzene-1,3,5-triphenol; and finally, condensing ethyl 4′-hydroxy-3′-methoxybenzoylacetate and (E)-2-(3,7-dimethyloct-2,6-dien-1-yl)benzene-1,3,5-triphenol at high temperature to produce cannflavin A and/or cannflavin C, and then carrying out separation and purification to obtain pure cannflavin A and cannflavin C.

Claims20

Dependent claims

A preparation method for a cannflavin compound, comprising the following steps:

condensing
and diethyl carbonate under an alkaline condition to obtain
reacting
with an alcohol compound (R3—OH) to obtain
and
reacting
with
to obtain the cannflavin compound;
wherein the cannflavin compound has a structure of general formula I:
R5, R6, R7, R5, and R9 are independently selected from the group consisting of:
H, C1-14 alkyl, C3-14 alkenyl, hydroxy, C1-5 alkoxy, carboxyl, amino, and halogen;
R2 and R4 are independently selected from the group consisting of:
H, C1-14 alkyl, C3-14 alkenyl, hydroxy, C1-5 alkoxy, carboxyl, and halogen;
and
R3 and R1 are independently selected from the group consisting of:
H, C1-14 alkyl, C3-14 alkenyl, and C1-5 alkoxy.

13 more elements

Dependencies are inferred from the claim text.

Preparation method for cannflavin compounds

Life of this patent

Preparation method for cannflavin compounds

Life of this patent

Abstract

Claims20