Tryptamine derivatives and their therapeutic uses

A tryptamine compound selected from the group consisting of a compound of formula (I):

• wherein:
• R1 is a straight chain or branched C2-C6 alkyl or a straight chain or branched C2-C6 alkenyl;
• R2 and R3 are independently chosen from hydrogen, hydroxyl, —OR9, —OC(O)R8, or —OC(O)OR4, —OSO2R4;
• R4 is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R8 is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R9 is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• and
• R5, R6 and R7 are each independently hydrogen or a straight chain or branched C1-C6 alkyl, or a pharmaceutically acceptable acid-addition salt thereof;
• and
• a compound of formula (Ia):
• wherein:
• R1a is a straight chain or branched C1-C6 alkyl or a straight chain or branched C2-C6 alkenyl;
• one of R2a and R3a is hydrogen and the other of R2a and R3a is selected from —OC(O)R8a, —OC(O)OR4a, and —OSO2R4a;
• R4a is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R8a is selected from straight chain or branched C1-C6 alkyl;
• R5a, R6a and R7a are each independently hydrogen or a straight chain or branched C1-C6 alkyl, or a pharmaceutically acceptable acid-addition salt thereof.

A tryptamine compound selected from the group consisting of a compound of formula (II):

• wherein:
• R1 is a straight chain or branched C1-C6 alkyl or a straight chain or branched C2-C6 alkenyl;
• R2 and R3 are both hydrogen;
• R4 and R6 are independently chosen from hydrogen, hydroxyl, —OR5, —OC(O)R11, —OC(O)OR12, —OSO2R12;
• R5 is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R11 is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R12 is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R7, R8 and R9 are each independently hydrogen or a straight chain or branched C1-C6 alkyl;
• and
• X− is a pharmaceutically acceptable anion;
• and
• a compound of formula (IIa):
• wherein:
• R1a is a straight chain or branched C1-C6 alkyl or a straight chain or branched C2-C6 alkenyl;
• R2a and R3a are both hydrogen;
• R4a and R6a are independently chosen from hydrogen, hydroxyl, —OR5a, —OC(O)R11a, —OC(O)OR12a, —OSO2R12a;
• R5a is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R11a is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R12a is a straight chain or branched C1-C6 alkyl or a substituted or unsubstituted aryl;
• R7a, R8a and R9a are each independently hydrogen or a straight chain or branched C1-C6 alkyl;
• and
• X2− is a pharmaceutically acceptable dianion.