Multi-channel integrated microfluidic chip and method for high-throughput preparation of monodisperse microgels using the same

A multi-channel integrated microfluidic chip, comprising at least two layers of channel structure, at least two liquid phase input channels, at least two drop-maker units and a collection channel;

• each layer of channel structure provided with a liquid phase input channel, wherein one of the layers of channel structure is provided with drop-maker units, and the collection channel is contained in one of the layers of channel structure or cross through the multiple layers of channel structure;
• each liquid phase input channel comprising at least one liquid phase input port (1), wherein the liquid phase input port (1) is connected to at least one resistance control unit (2), and each resistance control unit corresponding to one output port (3);
• the drop-maker unit comprising an input port (4), a liquid phase input channel (5), an emulsification channel (6), an output channel (7) and a local resistance control unit (8), wherein the output ports (3) on the different layers of channel structure correspond to the input ports (4) on the same and are communicated with each other through a microfluidic channel, and the resistance control units (2) on the same layer of channel structure are directly connected to the emulsification channel;
• and
• the collection channel comprising a washing channel (9), a washing phase input port (10) and a product output port (11).