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US 2023/0405583 A1Published application
Fluid Self -Modulation
Assignee1087 Systems, Inc.
InventorMATTHIAS WAGNER
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Abstract
Combining through self-modulation a flow of active media from a working vessel of a bioprocess together with a flow of reference media and making a time- and/or spatially-resolved referenced optical measurement of the active vs reference media in a confined flow region and time, such that the two liquids are measured in substantially identical conditions.
Claims1
A microfluid flow system comprising:
- a plurality of input ports, each of the plurality of input ports for receiving a liquid;
- a means for applying pressure to each received liquid;
- a liquid merge junction that merges the pressurized liquid from each of the plurality of input ports into a merged liquid flow in a microfluid flow channel;
- an obstruction disposed in the microfluid flow channel that creates a vortex shedding state of the merged liquid as the merged liquid flows past the obstruction;
- an optical interrogation region disposed at an optical sensing position downstream from the obstruction;
- an electromagnetic radiation source that delivers, at the optical interrogation region, electromagnetic radiation at one or more wavelengths relevant to an optical characteristic of the merged liquid;
- a detector that measures a result of the radiation interacting with the merged liquid at the optical interrogation region;
- and
- a computing system that receives an output of the detector and calculates a one or more of physical characteristics and biochemical characteristics of the merged liquid based on the output of the detector.
6 more elements
Dependencies are inferred from the claim text.