Method of removing protein-bound substances by electrically conductive polymer

A method of removing protein-bound substances by an electrically conductive polymer, comprising:

• (a) providing a PEDOT:PSS solution including carbon nanotubes and a crosslinking agent;
• (b) blending the PEDOT:PSS solution with an additive solution to acquire a quaternary blend solution;
• (c) electrospinning the quaternary blend solution to form the electrically conductive polymer;
• (d) using a first electrode and the electrically conductive polymer as a second electrode to coat on a dialysis membrane to acquire a bioelectronic interface device;
• (e) introducing a biological fluid sample to the bioelectronic interface device;
• and
• (f) providing an electrical stimulation to reduce binding rate between proteins and the protein-bound substances,
• wherein the additive solution is ranged 5˜30 wt % based on a total weight of the quaternary blend solution,
• wherein the additive solution comprises polyethylene oxide (PEO) solution, polyvinyl alcohol (PVA) solution, polyethyleneimine (PEI) solution, poly(acrylic acid) (PAA) solution, poly(styrenesulfonate) (PSS) solution, polyvinylpyrrolidone (PVP) solution, polyacrylamide (PAM) solution, poly(ethyl exazoline) solution, poly-lysine solution, poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) triblock copolymers solution, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymer solution, an alginate solution, hyaluronic acid (HA) solution, a gelatin solution, a collagen solution, polyglutamic acid (PGA) solution, a chitin solution, a chitosan solution, a cellulose solution or a combination thereof.