Systems and methods for targeted neuroregeneration
AssigneeThe Trustees of Columbia University in the City of New York
InventorsElisa KONOFAGOU, Antonios POULIOPOULOS
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Abstract
The present subject matter relates to techniques for treating a neurodegenerative disease. The disclosed system can include a transducer for stimulating a target tissue with focused ultrasound (FUS) and at least one nanocup. The transducer induces the FUS with a predetermined parameter to open the target tissue. The nanocup can include at least one gas pocket within a cavity of the nanocup and an effective amount of an active agent for neuroregeneration.
Claims20
A system for treating a neurodegenerative disease, comprising:
- a transducer for stimulating a target tissue with focused ultrasound (FUS), wherein the transducer induces the FUS with a predetermined parameter to open the target tissue;
- and
- at least one nanocup, wherein the nanocup comprises at least one gas pocket within a cavity of the nanocup, wherein the nanocup comprises an effective amount of an active agent for neuroregeneration.
The system of claim 5, wherein the microbubbles comprise at least one gas-filled cavity configured to act as a contrast agent in pulse inversion or full-waveform inversion ultrasound imaging.
A method for treating a neurodegenerative disease, comprising:
- administering at least one nanocup to a target tissue, wherein the nanocup comprises at least one gas pocket within a cavity of the nanocup, wherein the nanocup comprises an effective amount of an active agent for neuroregeneration;
- and
- applying FUS using a transducer, wherein the transducer induces the FUS with a predetermined parameter to open the target tissue, the predetermined parameter is selected from the group consisting of a center frequency, an outer diameter, an inner diameter, a radius of curvature, and a combination thereof.
The method of 18, wherein the applying FUS comprises applying a high-pressure FUS to trigger a release of an active agent from the nanocup, wherein the high-pressure ranges from about about 0.5 MPa to about 2 MPa.
Dependencies are inferred from the claim text.