Patient treatment systems for sensing cardiac depolarization and/or stimulating the carotid sinus nerve, and associated devices and methods

A patient treatment system, comprising:

• a neuromodulator comprising a housing, and at least one base electrode carried by the housing;
• an implantable signal delivery device electrically coupleable to the neuromodulator, the signal delivery device comprising a lead body including a first region, a second region positionable over the first region, a first set of lead electrodes at the first region, and a second set of lead electrodes at the second region, wherein the first and second sets of lead electrodes are electrically coupleable to the base electrode of the neuromodulator, and wherein the signal delivery device is configured to be implanted proximate to and/or at least partially around one or more nerves associated with a baroreflex of a patient;
• one or more processors;
• and
• tangible, non-transitory computer-readable media having instructions that, when executed by the one or more processors, cause the patient treatment system to perform operations comprising:
• obtaining a physiological parameter of the patient, wherein the physiological parameter comprises at least one of blood pressure, heart rate, bioimpedance, or patient activity level;
• based on the obtained physiological parameter, generating neuromodulation pulses;
• and
• delivering the neuromodulation pulses to the one or more nerves via one or more of the lead electrodes.