Vagus nerve stimulation pupillometry for electrode selection and titration

Abstract

The present disclosure generally relates to systems and methods for a stimulation system. Various aspects of the present disclosure relate generally to the treatment of epilepsy, depression and/or other conditions in a subject using a nerve stimulator and, more particularly, to an effective and quicker titration method for selection of stimulation parameters of the nerve stimulator using biological markers that indicate potential therapeutic effects. Some aspects of the present disclosure may utilize a pupillometry sensor synchronized with the VNS stimulation system to compare pupil size of a subject with stimulation on and off and for obtaining filtered pupil response measurements after stimulating each electrode while modulating the stimulation parameters. Thus, aspects of the present disclosure allow for quicker titration of programmable stimulation parameters (e.g., stimulation pulse amplitude) to levels that cause a therapeutic result in a matter of minutes instead of months as compared to related VNS systems.

Dependencies are inferred from the claim text.