Antimicrobial catheters
AssigneeBoard of Regents, The University of Texas System
InventorsJoel ROSENBLATT, Issam RAAD
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Abstract
Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided.
Claims189
A medical device comprising an aliphatic polyether polyurethane polymer having a durometer of A or B wherein the polyurethane is impregnated with minocycline and rifampin.
The medical device of claim 17, wherein m=1-50.
A medical device comprising an aliphatic polyether polyurethane polymer having a durometer of A or B wherein the polyurethane is impregnated with chlorhexidine, gendine, or gardine.
A medical device, comprising a polymer impregnated with minocycline and rifampin, wherein a surface of the polymer is coated with a polymer coating comprising a fatty acid or a guanidium compound.
The medical device of 40-50.3, wherein the polytetrafluoroethylene is TEFLON.
The medical device of any one of claims 1-96, wherein the aliphatic polyether polyurethane polymer is coated on the surface of the medical device.
An antimicrobial catheter, wherein the body of the catheter comprises an A durometer aliphatic polyether polyurethane polymer, wherein the polyurethane is impregnated either with
- (i) minocycline and rifampin;
- or
- (ii) chlorhexidine, gendine, or gardine.
A method of producing an antimicrobial polymer, comprising:
- (a) contacting an aliphatic polyether polyurethane with a solution comprising a first lower alcohol and at least one antimicrobial agent for an amount of time sufficient to impregnate the at least one antimicrobial agent in the aliphatic polyether polyurethane;
- wherein the solution does not contain a penetrating agent or an alkalizing agent;
- and
- (b) substantially drying the aliphatic polyether polyurethane.
A method of producing an antimicrobial polymer, comprising:
- (a) contacting a polymer with a solution comprising a lower alcohol, minocycline, rifampin, and an alkalizing agent for an amount of time sufficient to impregnate the minocycline and rifampin in the aliphatic polyether polyurethane;
- (b) exposing the polymer to a neutralizing solution comprising an alkanoic acid for an amount of time sufficient to substantially neutralize the alkalizing agent;
- and
- (c) substantially drying the polymer.
A catheter comprising a polymer tubing, wherein the polymer tubing is an aliphatic polyether polyurethane polymer, a polyurethane polymer coated with an aliphatic polyether polyurethane polymer, or a polytetrafluoroethylene polymer coated with an aliphatic polyether polyurethane polymer;
- wherein the polymer is coated or impregnated with chlorhexidine, gendine, gardine, minocycline, and/or rifampin.
Dependencies are inferred from the claim text.