Nanoparticle, photoacoustic contrast agent, photodynamic therapy drug, and photothermal therapy drug
AssigneeSumitomo Chemical Company, Limited
InventorsTakahiro SATO, Kentaro MASE, Kiyoshi HIGASHI
Life of this patent
Estimating the term…
Abstract
A nanoparticle including at least one amphiphilic molecule and a polymer compound having a constitutional unit represented by Formula (1): wherein, Ar1 and Ar2 represent a trivalent aromatic hydrocarbon ring group or a trivalent aromatic heterocyclic group; X and Y represent —O—, —S—, —C(═O)—, —S(═O)—, —SO2—, —CR2—, —SiR2—, —NR—, —BR—, —PR—, or —P(═O)(R)—; and R represents an alkyl group, aryl group, or the like; and n represents an integer of 1 or more.
Claims26
A nanoparticle comprising at least one amphiphilic molecule and a polymer compound having a constitutional unit represented by Formula (1):
- wherein, Ar1 and Ar2 each independently represent a trivalent aromatic hydrocarbon ring group or a trivalent aromatic heterocyclic group, and these groups optionally have a substituent;
- X and Y each independently represent —O—, —S—, —C(═O)—, —S(═O)—, —SO2—, —CR2—, —SiR2—, —NR—, —BR—, —PR—, or —P(═O)(R)—;
- R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a hydroxy group, an alkyloxy group, an aryl group, an aryloxy group, an arylalkyl group, an acyl group, an acyloxy group, an amide group, an amino group, a monovalent aromatic heterocyclic group, a heteroaryloxy group, a heteroarylthio group, a carboxyl group, an alkyloxycarbonyl group, an aryloxycarbonyl group, an arylalkyloxycarbonyl group, or a heteroaryloxycarbonyl group, and these groups optionally have a substituent;
- in the case that a plurality of Rs are present, they may be identical or different from each other,
- n represents an integer of 1 or more;
- and
- in the case that n is 2 or more, a plurality of Ys may be identical or different from each other.
A nanoparticle comprising a polymer compound having a group represented by Formula (5) and having a constitutional unit represented by Formula (1A):
- wherein, a3 represents an integer of 0 or 1 or more;
- R′ represents an alkylene group, a cycloalkylene group, or an arylene group, and these groups optionally have a substituent;
- in the case that a plurality of R′s are present, they may be identical or different from each other;
- R″ represents —Y31(R″2) or —Y31M;
- R″2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, or an aryl group, and these groups optionally have a substituent;
- M represents an alkali metal cation or a quaternary ammonium;
- Y31 represents —O—, —S—, —C(═O)O—, or —N(R″2)—;
- Y31A represents —O— or —S—;
- and
- in the case that a plurality of Y31As are present, they may be identical or different from each other, and
- wherein, Ar1 and Ar2 each independently represent a trivalent aromatic hydrocarbon ring group or a trivalent aromatic heterocyclic group, and these groups optionally have a substituent;
- XA and YA each independently represent —O—, —S—, —C(═O)—, —S(═O)—, —SO2—, —CRA2—, —SiRA2—, —NRA—, —BRA—, —PRA—, or —P(═O)(RA)—;
- RA represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a hydroxy group, an alkyloxy group, an aryl group, an aryloxy group, an arylalkyl group, an acyl group, an acyloxy group, an amide group, an amino group, a monovalent aromatic heterocyclic group, a heteroaryloxy group, a heteroarylthio group, a carboxyl group, an alkyloxycarbonyl group, an aryloxycarbonyl group, an arylalkyloxycarbonyl group, a heteroaryloxycarbonyl group, or the group represented by Formula (5), and a group other than the group represented by Formula (5) optionally has the group represented by Formula (5) or a substituent;
- in the case that a plurality of RAs are present, they may be identical or different from each other,
- nA represents an integer of 1 or more;
- and
- in the case that nA is 2 or more, a plurality of YAs may be identical or different from each other.
Dependencies are inferred from the claim text.