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US 2023/0405153 A1Published application
Fibroblast activation protein-targeted magnetic resonance imaging agents, compositions, and methods of use
AssigneePurdue Research Foundation
InventorsPhilip Stewart Low, Ramesh Mukkamala, Madduri Srinivasarao
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Abstract
A conjugate comprising FL-L-IA, wherein FL is a radical of a small molecule ligand that specifically binds with fibroblast activation protein (FAP), L is a linker, which binds an FL to IA, and IA is a radical of a magnetic resonance imaging (MRI) agent, or a pharmaceutically acceptable salt thereof; a composition comprising same; and a method of using the conjugate or composition to image cells, a tissue, or an organ that express(es) FAP with magnetic resonance imaging.
Claims27
A conjugate comprising:
- FL-L-IA,
- wherein FL is a radical of a small molecule ligand that specifically binds with fibroblast activation protein (FAP),
- L is a linker, which binds an FL to IA, and
- IA is a radical of a magnetic resonance imaging (MRI) agent,
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.