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AssigneeUniversity of Washington
InventorsMiqin Zhang, Richard G. Ellenbogen, Kui Wang, Forrest M. Kievit, John R. Silber, Zachary Stephen, Peter A. Chiarelli
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A nanoparticle for targeted siRNA delivery comprising an iron oxide core and a chitosan-polyethylene glycol-polyethylenimine copolymer coating surrounding the core, chlorotoxin covalently coupled to the coating, and an siRNA reversibly associated to the coating by non-covalent interaction. Methods for making the nanoparticle and methods for using the nanoparticle to suppress the expression of O6-methylguanine-DNA methyltransferase (MGMT), treating brain cancer, and killing cancer stem cells.
A nanoparticle for targeted siRNA delivery, comprising:
A nanoparticle for targeted siRNA delivery, consisting of:
A method for making a nanoparticle for targeted siRNA delivery, comprising contacting an siRNA with an iron oxide nanoparticle, wherein the iron oxide nanoparticle comprises an iron oxide core and a chitosan-polyethylene glycol-polyethylenimine copolymer coating surrounding the core, and a targeting agent covalently coupled to the coating.
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Dependencies are inferred from the claim text.