Loading patent…
AssigneeIndustry Foundation of Chonnam National University
InventorsSeong Young Kwon, Jung-Joon Min, Yeongjin Hong, Sung-Hwan You, Dong-Yeon Kim, Jin Hee IM
Estimating the term…
The present invention relates to host cells expressing monomeric streptavidin. The host cells according to the present invention may express streptavidin in vivo, making it possible to visualize and monitor in real time the biodistribution of cancer tissue, pre-targeted by the host cell, with a biotinylated diagnostic agent, as well as to increase the cancer-targeting efficiency of biotinylated anticancer drugs.
1-59. (canceled)
A composition comprising host cells transformed by introduction of a gene encoding biotin-binding protein thereinto.
A method for visualizing host cell biodistribution with imaging techniques, the method comprising a step of identifying monomeric streptavidin-expressing host cells after the host cells have been administered into a subject of interest.
A method for preventing or treating cancer, the method comprising administering to a subject in need thereof a composition comprising host cells transformed by introduction of a gene encoding monomeric streptavidin (mSA) thereinto.
Dependencies are inferred from the claim text.