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US 2023/0405122 A1Published application
Compositions and uses of psca targeted chimeric antigen receptor modified cells
AssigneeCity of Hope
InventorsJianhua Yu, Michael A. Caligiuri
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Abstract
Nucleic acid molecules encoding an IL-15 domain and a chimeric antigen receptor (CAR) that targets cells expressing prostate stem cell antigen are provided as well as polypeptides encoded thereby. Vectors and host cells such as immune cells containing the nucleic acid molecules also are disclosed, as well as methods for their use.
Claims46
A nucleic acid molecule comprising:
- (i) a first nucleotide molecule encoding a chimeric antigen receptor (CAR), and
- (ii) a second nucleotide molecule encoding an IL-15 domain,
- wherein the CAR comprises:
- a single chain variable fragment (scFv) targeting prostate stem cell antigen (PSCA), a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ξ signaling domain.
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Dependencies are inferred from the claim text.