Systems for buccal release of proteins
AssigneesCentre National De La Recherche Scientifique, Universite Claude Bernard Lyon 1
InventorsClaire Monge, Bernard Verrier, Anne-Lise Paris, Sofia Caridade
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Abstract
The present invention relates to a mucoadhesive patch for buccal or sublingual release of a protein or polypeptide, said patch comprising at least 100 bilayers each composed of a layer of chitosan (CHI) and a layer of an anionic polysaccharide. The invention also relates to a method for producing such a patch.
Claims14
A buccal or sublingual mucoadhesive patch, intended for buccal or sublingual release of a protein or of a polypeptide, said patch comprising at least 100 bilayers each made up of a layer of chitosan (CHI) and a layer of an anionic polysaccharide having a molecular weight between 500 and 1000 kDa or a salt thereof, wherein the layer in contact with the mucosa and the layer in contact with the buccal or sublingual environment of the patch consist of chitosan (CHI), and wherein said protein or said polypeptide are incorporated in said patch and/or adsorbed on the surface of said patch.
A method for desensitizing a subject allergic to an allergen, the method comprising administering to the subject said allergen in the form of a patch, wherein the allergen is a protein or polypeptide;
- the patch is a buccal or sublingual mucoadhesive patch comprising at least 100 bilayers, each made up of a layer of chitosan (CHI) and a layer of an anionic polysaccharide having a molecular weight between 500 and 1000 kDa or a salt thereof;
- the layer in contact with the mucosa and the layer in contact with the buccal or sublingual environment of the patch consist of chitosan (CHI);
- and said allergen is incorporated in said patch and/or adsorbed on the surface of said patch.
Dependencies are inferred from the claim text.