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US 2023/0405088 A1Published application
Pharmaceutical Composition of GLP-1/GLP-2 Dual Agonists
AssigneeZealand Pharma A/S
InventorsJesper Skodborg Villadsen, Lise Giehm
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Abstract
The present invention relates to pharmaceutical compositions comprising particular preservatives.
Claims21
A composition comprising:
- (a) one or more GLP-1/GLP-2 dual agonist comprising general formula A:
- H[Aib]EG-X5-F-X7-SELATILD-[ψ]-QAARDFIAWLI-X28-HKITD (A),
- wherein X5 is T or S;
- X7 is T or S;
- X28 is Q, E, A, H, Y, L, K, R or S and at least one of X5 and X7 is T,
- wherein [ψ] indicates an L or D lysine residue in which an albumin binding moiety is conjugated to the GLP-1/GLP-2 dual agonist, and
- wherein said albumin binding moiety is [K([17-carboxy-heptadecanoyl]-isoGlu)];
- (b) one or more preservative, wherein the one or more preservative is or comprises benzoate, benzalkonium chloride and/or benzyl alcohol;
- and
- (c) phosphate buffer.
7 more elements
Dependencies are inferred from the claim text.