Detection and treatment of intestinal fibrosis

Abstract

Methods and materials for measuring semm elafin levels, elevated levels of which have been confirmed to detect the presence of stricture in patients with Crohn's disease (CD), and a method for improving the accuracy of detecting the presence of stricture through the use of an algorithm developed through machine learning and/or through the use of clinical data. Further, materials and methods for treating intestinal stricture in a subject having Crohn's disease, as well as for inhibiting intestinal fibrosis, inflammatory bowel disease (IBD), metabolic disease, or obesity in a subject, comprises administering elafin to the subject.

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