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AssigneeCurigin Co., Ltd.
InventorsSeong Hoon PARK, Jung Ki YOO, Ki Hwan UM
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The present invention relates to a modified hTERT promoter for regulating cancer cell-specific gene expression and an oncolytic adenovirus including the same. The modified hTERT promoter of the present invention increases the cancer-specific transcriptional activity of a target gene compared to the case where a wild-type hTERT promoter is used, and when the modified hTERT promoter is used for an oncolytic adenovirus, the tumor-killing effect is excellent compared to the case where an adenovirus is prepared using the wild-type hTERT promoter.
A promoter in which a 228th nucleotide sequence of an hTERT promoter is substituted from C to T;
A composition for overexpressing a target gene in a cancer cell-specific manner comprising:
An oncolytic adenovirus comprising a cancer cell-specific promoter in which a 228th nucleotide sequence of an hTERT promoter is substituted from C to T;
Dependencies are inferred from the claim text.