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AssigneesAcademy of Military Medical Sciences, Academy of Military Sciences of Chinese Pla, Beijing Jiuyu Oncolgy Co., Ltd.
InventorsZhiqiang LIU, Zengqiang YUAN, Xiaowen XING, Bingshui XIU, Shihong LIU
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An application of hyaluronic acid in preparing medicines for preventing or treating ferroptosis-related diseases is provided, and an application of hyaluronic acid or salts of hyaluronic acid or derivatives of hyaluronic acid in preparing medicines for inhibiting ferroptosis is also provided. According to the present application, the anti-ferroptosis function of hyaluronic acid is disclosed. The hyaluronic acid is the first natural extracellular matrix material with anti-ferroptosis function found at present. The hyaluronic acid is one of the components of natural extracellular matrix and exists in large quantities in human body and is also a widely used material in clinic.
An application of hyaluronic acid or hyaluronates in preparing medicines for preventing or treating ferroptosis-related diseases, wherein a number-average molecular weight of the hyaluronic acid or its salts ranges from 730 kD-1500 kD, wherein the ferroptosis-related diseases are cerebral hemorrhage, brain periventricular leukomalacia, neurodegenerative disease and renal failure;
An application of hyaluronic acid or hyaluronates in preparing medicines for inhibiting ferroptosis, wherein a number-average molecular weight of the hyaluronic acid or the hyaluronates ranges from 730 kD-1500 kD, wherein the medicines are used for preventing or treating cerebral hemorrhage, brain periventricular leukomalacia, neurodegenerative disease and renal failure;
An ferroptosis inhibitor composition, comprising at least one of hyaluronic acid and hyaluronates and other ferroptosis inhibitors, wherein a number-average molecular weight of the hyaluronic acid or the hyaluronates ranges from 730 kD-1500 kD;
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