Lipid-like nanocomplexes and uses thereof

A compound of formula (I):

• or a salt thereof;
• wherein
• A, a hydrophilic head, is an amino moiety formed from
• B is C1-C24 alkyl, C2-C24 alkenyl, C2-C24 alkynyl, C3-C24 cycloalkyl, C1-C24 heteroalkyl, C1-C24 heterocycloalkyl, aryl, or heteroaryl, or
• each occurrence of R1 is independently a C1-C20 bivalent aliphatic radical;
• each occurrence of R2 is independently a bond or C1-C20 bivalent aliphatic radical;
• each occurrence of R3 and R4, independently, is H or C1-C10 alkyl, or R3 and R4, together with the atom to which they are attached, form C3-C10 cycloalkyl;
• each occurrence of R5 is independently
• in which each occurrence of R6 is independently a bond or C1-C20 bivalent aliphatic
• radical;
• each occurrence of Rb and Rb′ is independently F or, Rb and Rb′, together
• with the atom to which they are attached, form C═O;
• each occurrence of R7 is F or an
• aliphatic lipid moiety;
• each occurrence of L1 and L2, independently, is a bond, O, S,
• or NRc, each occurrence of Rc is independently H, C1-C10 alkyl, C1-C10 heteroalkyl,
• aryl, or heteroaryl;
• and n is independently at each occurrence an integer from 1 to 20;
• each occurrence of W and V, independently, is a bond, O, S, or Se;
• each occurrence of X, a linker, is independently
• in which each occurrence of L3, L4, L5, and L6, independently, is a bond, O, S, or NRc;
• each occurrence of G is independently O, S, or NRd;
• each occurrence of Q is independently ORf, SRg, or NRhR1;
• and each occurrence of r and t, independently, is 1-6, each occurrence of Rc, Rd, Re, Rf, Rg, Rh, and Ri, independently, is H, C1-C10 alkyl, C1-C10 heteroalkyl, aryl, or heteroaryl;
• and
• m is independently at each occurrence 0 or 1.