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US 2023/0405016 A1Published application
Heterocyclic modulators of lipid synthesis
AssigneeSagimet Biosciences Inc.
InventorsDouglas I. Buckley, Gregory Duke, Allan S. Wagman, Marc Evanchik, Robert S. Mcdowell
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Abstract
Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatopepatitis (NASH).
Claims20
A compound having Structure (VI-J):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H, —CN, halogen, C1-C4 straight or branched alkyl, —O—(C3-C5 cycloalkyl), or —O—(C1-C4 straight or branched alkyl), wherein:
- the C3-C5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom;
- and when R1 is not H, —CN or halogen, it is optionally substituted with one or more halogens;
- each R2 is independently H, halogen or C1-C4 straight or branched alkyl;
- R3 is H, —OH, or halogen;
- R21 is cyclobutyl, azetidin-1-yl, or cyclopropyl;
- R22 is H, halogen, or C1-C2 alkyl;
- R35 is —C(O)—R351, —C(O)—NHR351, —C(O)—O—R351 or S(O)2R351;
- and
- R351 is C1-C6 straight or branched alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl.
8 more elements
A compound having Structure (XI):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is H, —CN, halogen, C1-C4 straight or branched alkyl, —O—(C3-C5 cycloalkyl), or —O—(C1-C4 straight or branched alkyl), wherein:
- the C3-C5 cycloalkyl optionally includes an oxygen or nitrogen heteroatom;
- and
- when R1 is not H, —CN or halogen, it is optionally substituted with one or more halogens;
- each R2 is independently H, halogen or C1-C4 straight or branched alkyl;
- R3 is H, —OH, or halogen;
- R21 is cyclobutyl, azetidin-1-yl, or cyclopropyl;
- R22 is H, halogen, C1-C2 alkyl;
- and
- R351 is C1-C2 alkyl or C2—O—(C1-C2 alkyl).
8 more elements
Dependencies are inferred from the claim text.