Tablet for use in treating huntington's disease and method of making the same
AssigneePTC Therapeutics, Inc.
InventorsSwathi Pinnamaneni, Akm Nasir Uddin, Mandar Vasant Dali
Life of this patent
Estimating the term…
Abstract
The present description relates to a tablet formulation of 2-[3-(2,2,6,6-tetramethylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazol-2-yl)phenol, a compound for use in treating Huntington's disease, and a method of making the same.
Claims30
A tablet comprising, as an active ingredient, 2-[3-(2,2,6,6-tetramethylpiperidin-4-yl)-3H-[1,2,3]triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazol-2-yl)phenol (hereinafter Compound 1), or a pharmaceutically acceptable salt thereof, wherein Compound 1 is present in an amount from about 5% to about 30% by weight of the total weight of the tablet, an intragranular excipient, and an extragranular excipient;
- wherein the intragranular excipient comprises microcrystalline cellulose and a diluent;
- wherein the ratio of microcrystalline cellulose to diluent is about 1:1 to about 1:4 and the microcrystalline cellulose is present in an amount of about 15% to about 25% by weight of the total weight of the tablet;
- wherein the disintegrant is present in an amount of about 1% to about 3% of the total weight of the tablet;
- wherein povidone is present in an amount of 1% to about 5% by weight of the total weight of the tablet;
- and, wherein the extragranular excipient comprises an additional amount of the diluent and an additional amount of the disintegrant.
Dependencies are inferred from the claim text.