Back to results
US 2023/0404994 A1Published application
Markers of tissue aging and uses therefor
AssigneeThe University of Newcastle
InventorsRoger Smith, Kaushik Maiti
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeThe University of Newcastle
InventorsRoger Smith, Kaushik Maiti
Estimating the term…
Provided herein are methods of detecting or determining aging and/or oxidative damage in tissue, including placental tissue, skin, kidney and brain tissue. One embodiment provides a method for detecting or determining aging in body tissue, comprising measuring one or more markers of aldehyde oxidase 1 (AOX1) expression or activity in a biological sample, wherein the level of AOX1 expression or activity, or of the one or more markers, is indicative of aging in the tissue. Also provided herein are methods of treating a disease or condition associated with ageing or oxidative damage in one or more cells or tissues, comprising administering to a subject in need thereof an inhibitor of AOX1.
A method of treating a disease or condition associated with ageing or oxidative damage in one or more cells or tissues, the method comprising administering to a subject in need thereof an inhibitor of aldehyde oxidase 1 (AOX1).
A method of slowing ageing or oxidative damage in one or more cells or tissues, the method comprising exposing the one or more cells or tissues to an inhibitor of AOX1.
A method for preventing or reducing the risk of post-dated pregnancy or stillbirth, the method comprising administering to a pregnant subject an inhibitor of AOX1.
Dependencies are inferred from the claim text.