Grk2 inhibition by paroxetine ameliorates osteoarthritis
AssigneeThe Penn State Research Foundation
InventorFadia KAMAL
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Abstract
The present disclosure is directed to compositions and methods for the treatment of inflammation, particularly methods using compositions containing paroxetine or a pharmaceutically acceptable salt or derivative thereof.
Claims15
A pharmaceutical composition comprising paroxetine or a pharmaceutically acceptable salt or derivative thereof;
- and one or more pharmaceutical acceptable carriers;
- wherein the compound is present in an effective amount to increase PTH/PTH1R-mediated cAMP production by at least 2 fold.
A method of increasing PTH/PTH1R-mediated cAMP production in a subject in need thereof, the method comprising administering a paroxetine or a pharmaceutically acceptable salt or derivative thereof to the subject.
(canceled)
A method of treating an inflammatory disorder in a subject in need thereof, the method comprising administering a paroxetine or a pharmaceutically acceptable salt or derivative thereof to the subject.
(canceled)
Dependencies are inferred from the claim text.