Back to results
US 2023/0404968 A1Published application
Gamma Butyrolactone Derivatives for Inducing Differentiation in Neoplastic Cells
AssigneeAmir Salehi-Najafabadi
InventorsSepand Tehrani Fateh, Sahand Tehrani Fateh, Amir Salehi-Najafabadi
Life of this patent
Estimating the term…
Abstract
Gamma butyrolactone derivatives for inducing differentiation in a neoplastic cell and methods for inducing differentiation in a neoplastic cell by contacting the neoplastic cell with a subapoptotic concentration of a gamma butyrolactone derivative are provided.
Claims20
A method for treating a human having a neoplasm, the method comprising:
- contacting a neoplastic cell of the human, said neoplastic cell being associated with the neoplasm, with a subapoptotic concentration of a gamma butyrolactone derivative, or salt thereof, that induces differentiation in the neoplastic cell, the gamma butyrolactone derivative having the formula:
- wherein R, R′, and R″, are each independently selected from the group consisting of hydrogen, hydroxyl, NH2, Se, S, halogen, phenyl, benzyl, carboxylic acid, carbonyl, unsubstituted alkyl, substituted alkyl, unsubstituted alkene, substituted alkene, unsubstituted alkyne, substituted alkyne, unsubstituted aryl, substituted aryl, unsubstituted alkoxy, substituted alkoxy, ester, and N-homoserine,
- N-homoserine having the formula:
- wherein:
- (a) X is selected from the group consisting of C═O, C═S, C═NH, CHOH, CHSH, C, CH, and CH2,
- (b) Y, at each occurrence in the N-homoserine, is selected from the group consisting of a single bond, a double bond, and a triple bond,
- wherein,
- (i) if Y is a single bond, R1 and R2 are each present,
- (ii) if Y is a double bond, R1 is present and R2 is absent, and
- (iii) if Y is a triple bond, R1 and R2 are each absent;
- and
- (c) R1, at each occurrence in the N-homoserine, is independently selected from the group consisting of H, an acyl chain, and an alkyl group,
- (d) R2, at each occurrence in the N-homoserine, is independently selected from the group consisting of H, an acyl chain, and an alkyl group, and
- (e) n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11.
11 more elements
A method for inducing differentiation in a neoplastic cell, said neoplastic cell being associated with a neoplasm, the method comprising:
- contacting the neoplastic cell with a subapoptotic concentration of a gamma butyrolactone derivative, or salt thereof, that induces differentiation in the cancer cell, the gamma butyrolactone derivative having the formula:
- wherein R, R′, and R″, are each independently selected from the group consisting of hydrogen, hydroxyl, NH2, Se, S, halogen, phenyl, benzyl, carboxylic acid, carbonyl, unsubstituted alkyl, substituted alkyl, unsubstituted alkene, substituted alkene, unsubstituted alkyne, substituted alkyne, unsubstituted aryl, substituted aryl, unsubstituted alkoxy, substituted alkoxy, ester, and N-homoserine,
- N-homoserine having the formula:
- wherein:
- (a) X is selected from the group consisting of C═O, C═S, C═NH, CHOH, CHSH, C, CH, and CH2,
- (b) Y, at each occurrence in the N-homoserine, is selected from the group consisting of a single bond, a double bond, and a triple bond,
- wherein,
- (i) if Y is a single bond, R1 and R2 are each present,
- (ii) if Y is a double bond, R1 is present and R2 is absent, and
- (iii) if Y is a triple bond, R1 and R2 are each absent;
- and
- (c) R1, at each occurrence in the N-homoserine, is independently selected from the group consisting of H, an acyl chain, and an alkyl group,
- (d) R2, at each occurrence in the N-homoserine, is independently selected from the group consisting of H, an acyl chain, and an alkyl group, and
- (e) n is an integer selected from the group consisting of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11.
11 more elements
Dependencies are inferred from the claim text.