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US 2023/0404960 A1Published application
Disorders implicating pufa oxidation
AssigneeBioJiva LLC
InventorMikhail S. Shchepinov
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Abstract
Some aspects of the invention provide for a method of treating hepatic disorders, lipidemias and cardiac-related risk factors using polyunsaturated fatty acids which are modified in certain positions to attenuate oxidative damage by Reactive Oxygen Species (ROS) and/or suppress the rate of formation of reactive products and toxic compounds.
Claims2
A method of treating or inhibiting the progression of a hepatic disorder, comprising:
- administering an effective amount of a polyunsaturated substance to a patient having alcoholic fatty liver disease, non-alcoholic fatty liver disease, steatohepatitis, cirrhosis, hepatocellular carcinoma, obstructive jaundice, cholelitiasis, or a biliary tract disease and in need of treatment, wherein the polyunsaturated substance is chemically modified such that one or more bonds is stabilized against oxidation;
- wherein the polyunsaturated substance or a polyunsaturated metabolite thereof comprising said one or more stabilized bonds is incorporated into the patient's body following administration.
2-30. (canceled)
Dependencies are inferred from the claim text.