NON-CATIONIC SOFT POLYPHENOL NANOCAPSULES FOR EFFECTIVE SYSTEMIC DELIVERY OF SMALL INTERFERING RNA (siRNA) FOR CANCER TREATMENT

A composition of soft, non-cationic nanocapsules (Nanosac) useful for in vivo delivery of a therapeutic compound (TC) manufactured according to the steps of

• preparing the TC to be delivered;
• preparing an amine modified mesoporous silica nanoparticle (MSN);
• coating the MSN with the TC to afford TC-MSN;
• coating the TC-MSN with polydopamine (pD) to afford pD-TC-MSN;
• and
• dispersing the pD-TC-MSN in a buffered oxide etch solution to remove MSN and affording the Nanosac with the TC.

A method of intratumoral delivery of a therapeutic compound (TC) to a patient comprising preparing a dosage form of a composition of soft, non-cationic nanocapsules (Nanosac), wherein the Nanosac is manufactured according to a process of:

• preparing the TC to be delivered;
• preparing an amine modified mesoporous silica nanoparticle (MSN);
• coating the MSN with an amount of the TC to afford TC-MSN;
• coating the TC-MSN with polydopamine (pD) to afford pD-TC-MSN;
• and
• dispersing the pD-TC-MSN in a buffered oxide etch solution to remove MSN and affording the Nanosac with the TC;
• and
• systemically delivering the Nanosac composition to a tumor of the patient in a dose sufficient to achieve a therapeutic response.