Compositions And Methods For Treating With A Combination Of Alternating Electric Fields And Trastuzumab

Abstract

Disclosed are methods of treating a subject in need thereof comprising applying an alternating electric field, at a frequency for a period of time, to a target site of the subject in need thereof, and administering trastuzumab to the target site of the subject in need thereof. Disclosed are methods of increasing accumulation of trastuzumab at a target site of a subject in need thereof comprising applying an alternating electric field, at a frequency for a period of time, to the target site of the subject in need thereof; and administering trastuzumab to the target site of the subject in need thereof, wherein the accumulation of the trastuzumab increases at the target site compared to administering the trastuzumab at the target site without applying an alternating electric field. Disclosed are methods of inhibiting cancer cell proliferation or increasing apoptosis of cancer cells at a target site of a subject in need thereof comprising applying an alternating electric field, at a frequency for a period of time, to the target site of the subject in need thereof; and administering trastuzumab to the target site of the subject in need thereof, wherein cancer cell proliferation is inhibited or wherein apoptosis of cancer cells is increased.

Dependencies are inferred from the claim text.