Monolithic Implantable Device for Sustained Release of an Antibody
AssigneeCelanese EVA Performance Polymers LLC
InventorsJeffrey C. Haley, Vijay Gyanani, Harsh Patel
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Abstract
A monolithic implantable device for delivery of an antibody is provided. The implantable device comprises a polymer matrix within which is dispersed a pharmaceutical formulation that includes one or more therapeutic agents and optionally, one or more excipients. The therapeutic agents contain an antibody and the polymer matrix contains a hydrophobic polymer. Within a time period of 35 days, the device exhibits a cumulative weight-based release ratio of the antibody of from about 20% to about 60%.
Claims26
A monolithic implantable device for delivery of an antibody, the implantable device comprising a polymer matrix within which is dispersed a pharmaceutical formulation that includes one or more therapeutic agents and optionally, one or more excipients, wherein the therapeutic agents contain the antibody and the polymer matrix contains a hydrophobic polymer, wherein within a time period of 35 days, the device exhibits a cumulative weight-based release ratio of the antibody of from about 20% to about 60%.
Dependencies are inferred from the claim text.