Devices, systems, and methods for vessel assessment

An apparatus, comprising:

• a processor configured to:
• receive a first image of a blood vessel obtained at a first time, wherein the first image depicts a same location of the blood vessel with a first vessel structure;
• receive a second image of the blood vessel obtained at a second time, wherein the second image depicts the same location of the blood vessel with a second vessel structure;
• receive a third image of the blood vessel obtained at a third time, wherein the third image depicts the same location of the blood vessel with a third vessel structure;
• generate a screen display comprising:
• the first image;
• the second image;
• and
• the third image;
• and
• output the screen display on a display,
• wherein the first image, the second image, and the third image are displayed simultaneously in the screen display,
• wherein the first image, the second image, and the third image comprise a same imaging modality,
• wherein the first image is obtained before a therapy directed to the same location is performed,
• wherein at least one of the second image or the third image is obtained after the therapy directed to the same location is performed,
• wherein the therapy comprises at least one of percutaneous coronary intervention (PCI), angioplasty, stenting, coronary artery graft, ablation, cryotherapy, atherectomy, or administration of a drug, and
• wherein at least one of the second vessel structure or the third vessel structure is different than the first vessel structure as a result of a physiological change caused by the therapy.