Systems and methods for spatial entropyomics for the treatment of cancer

A method for developing a spatial entropyomic profile of a neoplasm, the method comprising the steps of:

• obtaining at least one biopsy from a neoplasmic mass;
• analyzing the at least one biopsy to derive a present state neoplasmic profile of the neoplasmic mass comprising at least one of:
• a genomic profile, an epigenetic profile, a micro-RNA network profile, a proteomic profile;
• identifying, from the present-state neoplasmic profile, a present-state driver zone of the neoplasmic mass, the present-state driver zone being the region of the neoplasmic mass displaying the highest cellular master regulator complex network entropy;
• and
• identifying, from an evolutionary projection of the present-state neoplasmic profile, one or more candidate future-state driver zones of the neoplasmic mass, a candidate future-state driver zone comprising a region of the neoplasmic mass having an elevated propensity to develop into a projected active future-state driver zone comprising a region of the neoplasmic mass displaying the highest cellular master regulator complex network entropy;
• wherein the height of the cellular master regulator complex network entropy of a given particular region of a neoplasmic mass is determined according to the magnitude of and confluence, relative to other regions of the neoplasmic mass, of a plurality of factors in that region including:
• elevated cellular entropy, elevated chromosomal instability, elevated intratumor heterogeneity, depressed transmembrane potential, elevated resistance to microenvironmental noxions to growth, elevating resistance to available pharmaceutical modalities, elevated resistance to survival inhibitory factors.