Method for neutralizing biotin interference in binding assays

A coated solid-phase system for neutralizing biotin interference in a binding assay for detection of an analyte in a sample, wherein:

• (i) the coating comprises an adsorbent substance, wherein the substance has a porous structure having a total surface area (SBet) of from 300 to 6500 m2 g−1 and has at least macropores, mesopores and micropores, wherein the volume of the micropores (Vmic) is from 0.15 to 0.75 cm3 g−1, wherein the substance is preferably activated carbon, a metal-organic framework (MOF), zeolite, clay, a porous organic polymer (POP), hydrotalcite, an organic-inorganic hybrid, a porous metal oxide, a lithium zirconate or a mesoporous silica material (MSM);
• and
• (ii) the solid phase is a filter, surface of a liquid container, pipette tip, or particle composed of latex, Sepharose, agarose, plastic, glass, protein, alginate, silicate or metal.